Platelet Rich Fibrin Matrix (PRFM) Injections in St. Louis, MO

Platelet Rich Plasma (PRP) therapies have been around for a while, widely recognized for their regenerative properties and potential to stimulate the body’s natural healing process. A newer advancement in this field is Platelet Rich Fibrin Matrix (PRFM).

What Is Platelet Rich Fibrin Matrix (PRFM)?

Platelet Rich Fibrin Matrix (PRFM) is a refined form of Platelet Rich Plasma (PRP). The process of creating PRFM involves isolating platelets from a small sample of the patient’s own blood, then stabilizing those platelets in a fibrin matrix. This matrix acts as a scaffold that holds and releases growth factors over a period of time, making it potentially more effective at supporting tissue repair and regeneration than standard PRP alone. In simpler terms, PRFM is your blood’s growth factors delivered in a controlled and more sustained manner—helping to stimulate natural healing and regeneration processes.

How the PRFM Process Is Done?

• Blood Draw - A small amount of blood is drawn from the patient—similar to a routine lab test.
• Centrifugation - The blood sample is placed in a specialized centrifuge that separates its components. Red blood cells, white blood cells, and platelets separate into distinct layers.
• Isolation of Platelets - The platelet-rich portion is then collected. In PRFM, an additional step is taken to create a fibrin matrix by adding a special reagent (often calcium chloride).
• Formation of the Fibrin Matrix - The reagent triggers a clotting cascade that helps form a thin, gel-like matrix—this is the “fibrin” in PRFM. It suspends the platelets in place so that growth factors are released more gradually.
• Injection/Application - The resulting PRFM is then applied or injected into the target area (e.g., the face, scalp, or another site requiring tissue rejuvenation).

What Is PRFM Used For?

PRFM has a wide range of potential applications in both medical and cosmetic settings. Common uses include:

• Facial Rejuvenation - Injected to help reduce fine lines, wrinkles, and improve overall skin tone and texture.
• Hair Restoration - Applied to the scalp to encourage hair regrowth and thicker, healthier strands.

Typical Treatment Areas:

• Face (around eyes, cheeks, and smile lines)
• Neck and Décolleté
• Hands
• Scalp
• Acne or Surgical Scars (to aid in scar revision)

Who Makes PRFM?

Several medical device companies offer kits and systems to produce PRFM. One recognized name in this category is the Selphyl System by Factor Medical. Doctors, med spas, and clinics may use various PRFM systems—all with a similar goal: to process the patient’s blood into a stable, fibrin-rich product packed with platelets and growth factors.

Who Is a Candidate for PRFM?

Most healthy adults looking to harness their body’s natural healing abilities for cosmetic or therapeutic purposes could be candidates. You may be a good candidate if:

• You desire natural-looking rejuvenation (face, neck, hands, hairline).
• You want minimal downtime and a procedure that uses your own biology (reducing the risk of allergic reactions).
• You have mild to moderate signs of aging or early hair thinning.
• You are not pregnant or nursing (always confirm with your healthcare provider).
• You do not have a history of severe bleeding disorders or active infections.
• Your provider will review your medical history to ensure PRFM is safe and appropriate for you.

Potential Side Effects

Like any procedure involving injections, there can be side effects. However, because PRFM is derived from your own blood, serious complications are rare. Potential side effects include:

• Mild swelling or bruising at the injection site
• Redness or tenderness
• Minor discomfort

These side effects typically resolve within a few days. Always follow your provider’s post-treatment instructions to minimize risk and ensure optimal results.

What Are the Benefits?

• Natural Solution - Uses your own blood, reducing the risk of allergic reactions or rejection.
• Longer-Lasting Release of Growth Factors - The fibrin matrix prolongs the release of platelets’ growth factors for potentially enhanced and more sustained results.
• Minimal Downtime - Most patients resume normal activities within a day or two.
• Versatile Treatment - Can be used for facial rejuvenation, hair restoration, scar improvement, and more.
• Improved Texture & Tone - Users often report smoother, firmer skin and more even tone.

General Questions

• How long does a PRFM treatment take? A typical session, including blood draw, processing, and injection, can take 30 to 60 minutes depending on the treatment area.
• How soon will I see results? Some immediate improvement may be noticed, particularly with skin volume (due to swelling), but significant changes often appear several weeks to months after treatment as new collagen and tissues regenerate.
• How many treatments do I need? This varies by individual and treatment goals. Many providers recommend 1-3 sessions spaced several weeks apart, then occasional maintenance treatments.
• Is PRFM painful? Discomfort is usually minimal. Providers often use topical numbing creams or local anesthesia to reduce any pain associated with injections.
• Is there any downtime? Most people experience little to no downtime. Mild swelling or redness may persist for a day or two.
• Can PRFM be combined with other treatments? Yes, many practices combine PRFM with microneedling, laser therapy, or dermal fillers for enhanced results. Always discuss combination treatments with your provider.
• How is PRFM different from PRP? PRFM takes PRP a step further by adding a fibrin matrix, which extends the release of platelets’ growth factors over a longer period. Many find PRFM may offer more sustained and potentially more effective results for certain indications.

Other Applicable Information

• Pre-Treatment Preparation - Your provider may suggest avoiding blood-thinning medications (e.g., NSAIDs, aspirin) and alcohol in the days leading up to treatment to reduce bruising.
• Post-Treatment Care - Gently wash the treated area as recommended, avoid strenuous exercise or excessive sun exposure for a short period, and follow any specific guidelines given by your provider.

Platelet Rich Fibrin Matrix (PRFM) represents a sophisticated and innovative step in regenerative medicine, providing a natural approach to facial rejuvenation, hair restoration, and accelerated healing in various medical and cosmetic applications. By harnessing the power of your own blood’s platelets and growth factors, PRFM offers minimal risks, quick recovery, and long-lasting improvements that align with the body’s inherent repair systems.

If you’re curious whether PRFM is right for you, consult with one of The Saint Louis Med Spa’s nurse injectors to see if Platelet Rich Fibrin Matrix is right for you. With the right provider, PRFM can be a rewarding choice to support your aesthetic and wellness goals.